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Tumor Differentiation-Dependent PET Radiotracer Uptake Patterns

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History

A 59 year-old female presented for imaging with a history of pancreatic neuroendocrine tumor with liver metastasis.


Findings

Images of all performed near the same timepoint.  

1: Fused Ga-68 DOTATATE PET/CT;  

2: Ga-68 DOTATATE PET Only;

3: Fused FDG PET/CT;

FDG PET Only,

Image 1:  The arrows are pointing at the primary pancreatic tail tumor/mass and demonstrates some FDG activity but marked avidity for Ga-68-DOTATATE.  

Image 2: The arrow is pointing at one of the hepatic metastatic lesions with central necrosis, no FDG avidity, and peripheral Ga-68 avidity.  

Image 3:  Nonenhanced CT shows multiple hepatic metastases.  


Diagnosis

Tumor Differentiation-Dependent PET Radiotracer Uptake Patterns


Discussion

Well-differentiated neuroendocrine tumors are often seen on Ga 68 SSTR imaging with increased uptake, while poorly-differentiated neuroendocrine tumors tend to be more FDG avid . The same patient may exhibit varying degrees of differentiation.



Author
Dr Saabry Osmany
Organization
ACNM
Channel
ACNM Clinical cases channel
Tumor Differentiation-Dependent PET Radiotracer Uptake Patterns Series 1

Series 1

Tumor Differentiation-Dependent PET Radiotracer Uptake Patterns Series 2

Series 2

Tumor Differentiation-Dependent PET Radiotracer Uptake Patterns Series 3

Series 3

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