There are two types of contrast agent based on superparamagnetic iron oxides: SPIO (Superparamagnetic Iron Oxide) for liver tropism and USPIO (Ultrasmall Superparamagnetic Iron Oxide) for ganglion tropism.
These particles have a predominant T2 effect (magnetic susceptibility) and produce a drop in signal namely in T2* weighting. This hyposignal is found in areas of normal tissue (reticuloendothelial system), which takes up the iron oxide particles, as opposed to zones with metastatic invasion.

Brand names

  • Endorem® / Feridex® (AMI-25)
  • Resovist® / Cliavist® (SH U 555A)
  • Sinerem® / Combidex® (AMI-227)