The hepatocytes (hepatic cells) are polyhedral in form. They vary in size from 12 to 25µ in diameter. They contain one or sometimes two distinct nuclei. The nucleus exhibits an intranuclear network and one or two refractile nucleoli. The cells usually contain granules; some of which are protoplasmic, while others consist of glycogen, fat, or an iron compound.
Hepatocytes are organised into plates separated by vascular channels (sinusoids), an arrangement supported by a reticulin (collagen type III) network. The hepatocyte plates are one cell thick in mammals.
The hepatocyte also initiates formation and secretion of bile.