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Incidental Uptake on PET

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Historial

69 year-old female patient with multiple myeloma had undergone sequential FDG PET-CT studies to assess for disease activity after chemotherapy. 

1) What incidental finding of clinical importance is noted in three sequential scans?

2) What is the clinical significance of the variation of the intensity of FDG uptake FDG in the organ of interest with this ancillary finding?

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Diffuse thyroid uptake attributed to hypothyroidism  PET-CT

PET-CT

Diffuse thyroid uptake attributed to hypothyroidism   PET Screenshot

PET Screenshot